In 1995, the National Institute ofNeurologicalDisorders and Stroke (NINDS) study group reported thatpatients withacute ischemic stroke who received alteplase withinthreehours
after the onset of symptoms were at least 30% more likely tohaveminimal or no disability at three months than those whoreceivedplacebo. A subsequent study demonstrated that patientstreated withrt-PA were also more likely to
have minimal or no disability at one-year follow-up.